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KMID : 1123920080220040878
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 4 p.878 ~ p.883
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Inhibitory Effect of Oyster Conchioloin on Pro-inflammatory Mediator in Lipopolysaccharide;Activated Raw 264.7 Cells
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Park Sang-Mi
Zhao Rong-Jie
Lee Jong-Rok
Lee Chul-Won
Kim Hak-Ju
Kwon Young-Kyu
Kim Sang-Chan
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Abstract
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Conchiolin is a complex protein which is secreted by the mollusc’s outer epithelium to be the organic basis of mollusc shell. This study is to investigate a potential anti-inflammatory activity of conchiolin of oyster shell (COS). We tested the effects of COS on the lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin E2 (PGE 2) in a murine macrophage cell line, RAW 264.7. COS inhibited production of NO and PGE2 in a dose dependent manner and also decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis () and interleukin-6 (IL-6). These results suggest that COS can inhibit production of pro-inflammatory mediators and might be a useful source to treat inflammation.
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KEYWORD
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Conchiolin, Shell of oyster, iNOS, COX-2
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